| Date | Opponent(s) | Result | Caption | Location | Transportation | |
|---|---|---|---|---|---|---|
| 8/27/21 |
vs
Louisa-Muscatine
|
W 9-6 | Columbus High School | |||
| 9/3/21 |
vs
Highland
|
L 20-48 | Columbus High School | |||
| 9/10/21 |
vs
Wapello
|
L 21-52 | Wapello High School | |||
| 9/17/21 |
@
Lisbon
|
L 0-40 |
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Lisbon Community High School | ||
| 9/24/21 |
vs
Pekin
|
W 42-14 | Columbus High School | |||
| 10/1/21 |
vs
North Mahaska
|
L 10-12 | North Mahaska High School | |||
| 10/8/21 |
vs
North Cedar
|
W 35-16 | Columbus High School | |||
| 10/15/21 |
@
Alburnett
|
L 9-13 | Alburnett Martin Complex |
