| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/29/2025 |
@
Central New Madrid County #619
|
W 21-6 | 301 US-61 | |
| 9/5/2025 | vs St. Charles West #617 | W 26-7 | Cape Central High School Tiger Stadium | Tiger Tailgate sponsored by the Booster Club |
| 9/12/2025 |
@
Sikeston #615
|
W 33-14 | Sikeston High School Sikeston Public Schools Stadium | |
| 9/19/2025 |
vs
Poplar Bluff #614
|
W 28-22 | Cape Central High School Tiger Stadium | |
| 9/26/2025 | @ St. Dominic #3 | L 7-20 | St. Dominic High School | |
| 10/3/2025 |
@
Jackson #4
|
L 24-62 | Jackson High School | |
| 10/10/2025 |
vs
Farmington #1
|
L 21-35 | Cape Central High School Tiger Stadium | Future Tiger Night |
| 10/17/2025 |
vs
Lift for Life #621
|
W 17-16 | Cape Central High School Tiger Stadium | Senior Night / Teacher Appreciation Night |
| 10/24/2025 |
@
Kennett #620
|
W 35-8 | Kennett High School | |
| 10/30/2025 | vs Mehlville #618 | W 44-0 | Cape Central High School Tiger Stadium | |
| 11/7/2025 | vs Webster Groves #616 | W 50-14 | Cape Central High School Tiger Stadium | |
| 11/14/2025 |
@
Farmington #1
|
L 0-21 | Farmington High School | District Championship |
