| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
vs
Pierre T.F. Riggs #31
|
W 56-20 | Harrisburg High School | |
| 9/4/2021 |
vs
O'Gorman #34
|
W 44-24 | Harrisburg High School | Tiger Bowl |
| 9/10/2021 |
@
Sioux Falls Lincoln #35
|
W 35-28 | Howard Wood Field | Presidents Bowl |
| 9/17/2021 |
vs
Sioux Falls Washington #38
|
W 29-23 | Harrisburg High School | Homecoming |
| 9/24/2021 |
@
Sioux Falls Roosevelt #39
|
W 38-34 | Howard Wood Field | HOMECOMING |
| 10/1/2021 |
@
Rapid City Stevens #60
|
W 49-25 | O'Harra Stadium | Homecoming |
| 10/8/2021 |
vs
Rapid City Central #114
|
W 62-12 | Harrisburg High School | |
| 10/15/2021 |
vs
Sioux Falls Jefferson #47
|
W 42-24 | Harrisburg High School | |
| 10/21/2021 |
@
Brandon Valley #10
|
W 43-14 | Brandon Valley High School | Senior Night |
| 10/28/2021 |
vs
Rapid City Stevens #60
|
W 50-9 | Harrisburg High School | Class 11AAA - State Quarterfinal |
| 11/5/2021 |
vs
Sioux Falls Lincoln #35
|
W 17-10 | Harrisburg High School | Class 11AAA - State Semifinal |
| 11/13/2021 |
vs
Brandon Valley #10
|
W 27-0 | DakotaDome | Class 11AAA - State Championship |
