| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2022 |
vs
Aberdeen Central #66
|
W 54-15 | Hollister Football Field | |
| 9/2/2022 |
@
Brookings #85
|
W 48-0 | SDSU - Dana J. Dykhouse Stadium | |
| 9/10/2022 |
vs
Mitchell #106
|
W 50-6 | Hollister Football Field | |
| 9/16/2022 |
vs
Yankton #72
|
W 55-10 | Hollister Football Field | Homecoming |
| 9/23/2022 |
@
Watertown #94
|
W 47-13 | Watertown Football Stadium | |
| 9/30/2022 |
@
Brandon Valley #55
|
W 43-34 | Brandon Valley High School | |
| 10/7/2022 |
@
Huron #114
|
W 59-7 | Tiger Stadium | Senior Night |
| 10/14/2022 |
vs
Tea Area #19
|
W 35-30 | Hollister Football Field | Senior Night |
| 10/20/2022 |
@
Douglas #136
|
W 46-6 | Douglas High School | Senior & Parent Night |
| 10/27/2022 |
vs
Sturgis Brown #111
|
W 42-14 | Hollister Football Field | Class 11AA - State Quarterfinal |
| 11/4/2022 |
vs
Yankton #72
|
W 59-31 | Hollister Football Field | Class 11AA - State Semifinal |
| 11/12/2022 |
vs
Tea Area #19
|
W 35-20 | DakotaDome | Class 11AA - State Championship |
